E-HERBARIA

  • Name : Shati-Kachura
  • English Name :Zedoary
  • Scientific Name :Curcuma zedoaria

Habitat:

Karchura consists of dried pieces of rhizome of Curcuma zedoaria Rose, (Fam. Zingiberaceae), a large perennial herb with underground tuberous root-stock, growing wildly in eastern Himalayas and in moist deciduous forests of the central region of Karnataka; also cultivated throughout the country.1

Morphology Description :

Drug occurs as whole or longitudinally and tangentially cut pieces; the whole drug 2 to 6 cm long, cylindrical; transversely cut pieces 2 to 3.5 cm in dia., surfaces rough due to longitudinal wrinkles and occasional protuberances; nodes and internodes distinct, a few pieces bear thin root and root scars at places; colour externally greyish buff and internally cream; odour, camphoraceous; taste, slightly bitter.1

Parts Used:            Rhizome

Phytochemistry:

Essential oil and resin.

As per Ayurveda:

Rasa (Taste)                  Pungent, bitter

Guna (Property)            Light, Sharp

Veerya (Potency)           Hot

Vipaka (End Result)     Pungent

Pharmacological Actions:

Karchura is Vatakaphahara; its primary pharmacological actions are summarized as under:

Respiratory System:  

i. Exhibits anti-allergic activity.2

Digestive System: 

i. The Curcuma zedoaria rhizome has been used traditionally to treat gastrointestinal diseases as an aromatic stomachic drug, and this is currently used to treat alcohol-induced loss of appetite and nausea in Japan. It has been observed that the protective effect of the C. zedoaria extract on drunkenness might be due to an active substance, curcumenone, and decreases in the elevation of blood alcohol concentrations through increased liver alcohol dehydrogenase activity.3  

Others: 

i. The essential oil has the antimicrobial activity against some of Gram- positive and negative pathogenic microorganisms and the components of the extract lead to the apoptosis of human cancer cell line.4

ii. Possesses significant antibacterial and antifungal activities.5

iii. Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. Curdione, an active component of Shati, helps inhibit overproduction of prostaglandin E2.6

iv. Shati may play important roles in the inhibition of cancer metastasis.7

v. Exhibits considerable anti-inflammatory activity.8

Indications:

 Allergic and Inflammatory manifestations of Respiratory tract

 Musculoskeletal inflammations

 Skin infections

 Digestive ailments

References:

1. The Ayurvedic Pharmacopoeia of India, Part-1, Vol-1.

2. Matsuda H, Tewtrakul S, Morikawa T, Nakamura A, Yoshikawa M. Anti-allergic principles from Thai zedoary: structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorg Med Chem. 2004 Nov 15;12(22):5891-8.

3. Kimura Y, Sumiyoshi M, Tamaki T. Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice. Fitoterapia. 2013 Jan;84:163-9.

4. Lai EY, Chyau CC, Mau JL, et al. Antimicrobial activity and cytotoxicity of the essential oil of Curcuma zedoaria. Am J Chin Med. 2004;32(2):281-90.

5. Wilson B, Abraham G, Manju VS, et al. Antimicrobial activity of Curcuma zedoaria and Curcuma malabarica tubers. J Ethnopharmacol. 2005 May 13;99(1):147-51.

6. Oh OJ, Min HY, Lee SK. Inhibition of inducible prostaglandin E2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria. Arch Pharm Res. 2007 Oct;30(10):1236-9.

7. Seo WG, Hwang JC, Kang SK, te al. Suppressive effect of Zedoariae rhizoma on pulmonary metastasis of B16 melanoma cells. J Ethnopharmacol. 2005 Oct 3;101(1-3):249-57.

8. Makabe H, Maru N, Kuwabara A, et al. Anti-inflammatory sesquiterpenes from Curcuma zedoaria. Nat Prod Res. 2006 Jun;20(7):680-5.

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